Abstract:

 Objective To observe the safety and efficacy of domestic radioactive applicator for treatment of Sturge-Weber syndrome with exudative retinal detachment. Design Retrospective study. Participants 15 patients of Sturge-Weber syndrome with exudative retinal detachment that were treated with domestic radioactive applicator in Beijing Tongren Hospital from June 2009 to June 2018. Methods We recorded the data of visual acuity, intraocular pressure, size of the tumor(maximum base diameter, maximum height) measured by color Doppler imaging (CDI), changes in the subretinal fluid observed by indirect ophthalmoscope, CDI and OCT, and the data were retrospectively analyzed using SPSS 22.0. Main Outcome Measures Visual acuity, intraocular pressure, size of the tumor, changes in the subretinal fluid, occurrence rates of complications. Results Visual acuity significantly improved at latest follow-up (average follow-up was 48 months) (pre-operation 0.01±0.02, latest follow-up 0.05±0.11，P<0.01). Intraocular pressure remained similar (pre-operation19.9±12.1 mmHg, latest follow-up 15.6±2.4 mmHg，P=0.132). Tumor regressed in all cases (maximum basal diameter, pre-operation 16.0±3.2 mm, latest follow-up 13.9±3.9 mm, P<0.01; maximum height, pre-operation 6.5±2.0 mm, latest follow-up 2.7±1.5 mm, P<0.01). No subretinal fluid was observed by indirect ophthalmoscope, CDI or OCT at the latest follow-up except for 1 case. Conclusion It seems to be a good choice to treat the Sturge-Weber syndrome with severe exudative retinal detachment by domestic radioactive applicator. (Ophthalmol CHN, 2019, 28: 125-128)

Key words:  Sturge-Weber syndrome, choroidal hemangioma, plaque radiotherapy, Iodine125